Immune-inflammatory system and fatigue

  1. Chronic inflammation alters the quality of the athlete's sleep by causing the sleep does not exert its restorative function on the human organism.

    The international scientific community (International Classification of Sleep Disorders -ICSD-) defines this disorder as NRS (nonrestorative sleep). (Abhijit Deshpande et al.2018).

  2. Chronic Inflammation impairs cognitive ability (attention). (A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis Andrew Schrepf et al.2018).

    The increase in interneuronal activity between DAN and RmPFC as a consequence of chronic inflammation increase the sensations of fatigue and pain.

  3. Chronic Inflammation causes loss of muscle mass.

    (Stat 3 in skeletal muscle function and disorders, Guadagnin E. et al.2018).

    IL 6 favors protein degradation and subsequent loss of muscle mass.

  4. Chronic Inflammation increases the intensity and number of URTI (upper respiratory tract infections). (Respiratory inflammation and infections, David B Pyne et al.2016).

    The Natural Killer Cells decrease their concentration after high intensity training and/or competition.

  5. Chronic Inflammation decreases Mitochondrial Biogenesis by decrease the activation of PGC-1a, NRF-1, and Sirt-1.

     (Control of gene expression and mitochondrial biogenesis in the muscular adaptation to endurance exercise. Joseph A.M. et al.,  2006).

     In many sports 70% of the production of ATP occurs in the  mitochondria.

  6. Chronic Inflammation favors insulin resistance (IR).

    (Insulin resistance and chronic inflammation. Matulewicz N. et al ., 2016)

    Chronic inflammation favors IR that generates chronic inflammation. A devastating vicious circle for health and performance.

  7. Chronic inflammation accelerates the destruction of cartilage. (Rezus E. et al., 2019).

  8. Chronic inflammation compromises chondrocyte activity, hindering cartilaginous regeneration.